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Many studies indicate that environmental enrichment based on cognitive, sensory, and motor stimulation induces neuron remodelling and enhances cognitive and physical performance in animal models of AD, PD, ALS, and HD [203]

AT2 cells were seeded in 96-well plates (5,000 cells/well) for CCK-8 and LDH assays or 6-well plates (1105 cells/well) for cell death detection

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The result showed that mutations at sites of K38, K126, or K326 substantially decrease the succinylation level of GCLC, and simultaneously mutating all these three sites led to a nearly undetectable level of succinylation modification (Figs

Ghezzo A, Salvioli S, Solimando MC, Palmieri A, Chiostergi C, Scurti M, Lomartire L, Bedetti F, Cocchi G, Follo D, Pipitone E, Rovatti P, Zamberletti J, Gomiero T, Castellani G, Franceschi C